Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro

Cisplatin (cisPt), Pt(NH(3))(2)Cl(2), is a cancer drug believed to kill cells via DNA binding and damage. Recent work has implied that the cellular copper (Cu) transport machinery may be involved in cisPt cell export and drug resistance. Normally, the Cu chaperone Atox1 binds Cu(I) via two cysteines...

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Detalhes bibliográficos
Main Authors: Palm, Maria E., Weise, Christoph F., Lundin, Christina, Wingsle, Gunnar, Nygren, Yvonne, Björn, Erik, Naredi, Peter, Wolf-Watz, Magnus, Wittung-Stafshede, Pernilla
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084073/
https://ncbi.nlm.nih.gov/pubmed/21482801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012899108
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