Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro

Cisplatin (cisPt), Pt(NH(3))(2)Cl(2), is a cancer drug believed to kill cells via DNA binding and damage. Recent work has implied that the cellular copper (Cu) transport machinery may be involved in cisPt cell export and drug resistance. Normally, the Cu chaperone Atox1 binds Cu(I) via two cysteines...

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Hlavní autoři: Palm, Maria E., Weise, Christoph F., Lundin, Christina, Wingsle, Gunnar, Nygren, Yvonne, Björn, Erik, Naredi, Peter, Wolf-Watz, Magnus, Wittung-Stafshede, Pernilla
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2011
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084073/
https://ncbi.nlm.nih.gov/pubmed/21482801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012899108
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