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The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65–Prp19 complex

Pre-mRNA splicing is frequently coupled to transcription by RNA polymerase II (RNAPII). This coupling requires the C-terminal domain of the RNAPII largest subunit (CTD), although the underlying mechanism is poorly understood. Using a biochemical complementation assay, we previously identified an act...

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Detalhes bibliográficos
Main Authors: David, Charles J., Boyne, Alex R., Millhouse, Scott R., Manley, James L.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084030/
https://ncbi.nlm.nih.gov/pubmed/21536736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2038011
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