Naturally occurring single amino acid replacements in a regulatory protein alter streptococcal gene expression and virulence in mice

Infection with different strains of the same species of bacteria often results in vastly different clinical outcomes. Despite extensive investigation, the genetic basis of microbial strain-specific virulence remains poorly understood. Recent whole-genome sequencing has revealed that SNPs are the mos...

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Detalhes bibliográficos
Main Authors: Carroll, Ronan K., Shelburne, Samuel A., Olsen, Randall J., Suber, Bryce, Sahasrabhojane, Pranoti, Kumaraswami, Muthiah, Beres, Stephen B., Shea, Patrick R., Flores, Anthony R., Musser, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083769/
https://ncbi.nlm.nih.gov/pubmed/21490401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45169
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