A Naturally Occurring Single Amino Acid Replacement in Multiple Gene Regulator of Group A Streptococcus Significantly Increases Virulence

Single-nucleotide polymorphisms (SNPs) are the most common source of genetic variation within a species; however, few investigations demonstrate how naturally occurring SNPs may increase strain virulence. We recently used group A Streptococcus as a model pathogen to study bacteria strain genotype–pa...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Sanson, Misu, O'Neill, Brian E., Kachroo, Priyanka, Anderson, Jeff R., Flores, Anthony R., Valson, Chandni, Cantu, Concepcion C., Makthal, Nishanth, Karmonik, Christof, Fittipaldi, Nahuel, Kumaraswami, Muthiah, Musser, James M., Olsen, Randall J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2015
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4305177/
https://ncbi.nlm.nih.gov/pubmed/25476528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.10.018
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