Distinct Single Amino Acid Replacements in the Control of Virulence Regulator Protein Differentially Impact Streptococcal Pathogenesis

Sequencing of invasive strains of group A streptococci (GAS) has revealed a diverse array of single nucleotide polymorphisms in the gene encoding the control of virulence regulator (CovR) protein. However, there is limited information regarding the molecular mechanisms by which CovR single amino aci...

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Bibliographic Details
Main Authors: Horstmann, Nicola, Sahasrabhojane, Pranoti, Suber, Bryce, Kumaraswami, Muthiah, Olsen, Randall J., Flores, Anthony, Musser, James M., Brennan, Richard G., Shelburne, Samuel A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197619/
https://ncbi.nlm.nih.gov/pubmed/22028655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002311
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