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Controlling the activity of the Tec kinase Itk by mutation of the phenylalanine gatekeeper residue
The regulatory spine is a set of conserved residues that are assembled and disassembled upon activation and inactivation of kinases. We recently identified the regulatory spine within the immunologically important Tec family kinases and have shown that in addition to the core spine residues within t...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3083488/ https://ncbi.nlm.nih.gov/pubmed/21138328 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101379m |
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