Comprehensive long-span paired-end-tag mapping reveals characteristic patterns of structural variations in epithelial cancer genomes

Somatic genome rearrangements are thought to play important roles in cancer development. We optimized a long-span paired-end-tag (PET) sequencing approach using 10-Kb genomic DNA inserts to study human genome structural variations (SVs). The use of a 10-Kb insert size allows the identification of br...

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Autors principals: Hillmer, Axel M., Yao, Fei, Inaki, Koichiro, Lee, Wah Heng, Ariyaratne, Pramila N., Teo, Audrey S.M., Woo, Xing Yi, Zhang, Zhenshui, Zhao, Hao, Ukil, Leena, Chen, Jieqi P., Zhu, Feng, So, Jimmy B.Y., Salto-Tellez, Manuel, Poh, Wan Ting, Zawack, Kelson F.B., Nagarajan, Niranjan, Gao, Song, Li, Guoliang, Kumar, Vikrant, Lim, Hui Ping J., Sia, Yee Yen, Chan, Chee Seng, Leong, See Ting, Neo, Say Chuan, Choi, Poh Sum D., Thoreau, Hervé, Tan, Patrick B.O., Shahab, Atif, Ruan, Xiaoan, Bergh, Jonas, Hall, Per, Cacheux-Rataboul, Valère, Wei, Chia-Lin, Yeoh, Khay Guan, Sung, Wing-Kin, Bourque, Guillaume, Liu, Edison T., Ruan, Yijun
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2011
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083083/
https://ncbi.nlm.nih.gov/pubmed/21467267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.113555.110
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