Transcriptional consequences of genomic structural aberrations in breast cancer

Using a long-span, paired-end deep sequencing strategy, we have comprehensively identified cancer genome rearrangements in eight breast cancer genomes. Herein, we show that 40%–54% of these structural genomic rearrangements result in different forms of fusion transcripts and that 44% are potentially...

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Detalhes bibliográficos
Principais autores: Inaki, Koichiro, Hillmer, Axel M., Ukil, Leena, Yao, Fei, Woo, Xing Yi, Vardy, Leah A., Zawack, Kelson Folkvard Braaten, Lee, Charlie Wah Heng, Ariyaratne, Pramila Nuwantha, Chan, Yang Sun, Desai, Kartiki Vasant, Bergh, Jonas, Hall, Per, Putti, Thomas Choudary, Ong, Wai Loon, Shahab, Atif, Cacheux-Rataboul, Valere, Karuturi, Radha Krishna Murthy, Sung, Wing-Kin, Ruan, Xiaoan, Bourque, Guillaume, Ruan, Yijun, Liu, Edison T.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083084/
https://ncbi.nlm.nih.gov/pubmed/21467264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.113225.110
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