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Dominant Prion Mutants Induce Curing Through Pathways That Promote Chaperone-Mediated Disaggregation
Protein misfolding underlies many neurodegenerative diseases, including the Transmissible Spongiform Encephalopathies (prion diseases). While cells typically recognize and process misfolded proteins, prion proteins evade protective measures by forming stable, self-replicating aggregates. However, co...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3082495/ https://ncbi.nlm.nih.gov/pubmed/21423195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2031 |
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