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A dominant-negative mutant inhibits multiple prion variants through a common mechanism
Prions adopt alternative, self-replicating protein conformations and thereby determine novel phenotypes that are often irreversible. Nevertheless, dominant-negative prion mutants can revert phenotypes associated with some conformations. These observations suggest that, while intervention is possible...
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| Published in: | PLoS Genet |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Public Library of Science
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5679637/ https://ncbi.nlm.nih.gov/pubmed/29084237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007085 |
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