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A Size Threshold Limits Prion Transmission and Establishes Phenotypic Diversity
According to the prion hypothesis, atypical phenotypes arise when a prion protein adopts an alternative conformation and persist when that form assembles into self-replicating aggregates. Amyloid formation in vitro provides a model for this protein-misfolding pathway, but the mechanism by which this...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3003433/ https://ncbi.nlm.nih.gov/pubmed/21030659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1197785 |
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