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Nucleation seed size determines amyloid clearance and establishes a barrier to prion appearance in yeast
Amyloid appearance is a rare event that is promoted in the presence of other aggregated proteins. These aggregates were thought to act by templating the formation of an assembly-competent nucleation seed, but we find an unanticipated role for them in enhancing the persistence of amyloid after it ari...
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| 出版年: | Nat Struct Mol Biol |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7293557/ https://ncbi.nlm.nih.gov/pubmed/32367069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0416-6 |
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