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Nucleation seed size determines amyloid clearance and establishes a barrier to prion appearance in yeast

Amyloid appearance is a rare event that is promoted in the presence of other aggregated proteins. These aggregates were thought to act by templating the formation of an assembly-competent nucleation seed, but we find an unanticipated role for them in enhancing the persistence of amyloid after it ari...

詳細記述

保存先:
書誌詳細
出版年:Nat Struct Mol Biol
主要な著者: Villali, Janice, Dark, Jason, Brechtel, Teal M., Pei, Fen, Sindi, Suzanne S., Serio, Tricia R.
フォーマット: Artigo
言語:Inglês
出版事項: 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7293557/
https://ncbi.nlm.nih.gov/pubmed/32367069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0416-6
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