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Dominant Prion Mutants Induce Curing Through Pathways That Promote Chaperone-Mediated Disaggregation

Protein misfolding underlies many neurodegenerative diseases, including the Transmissible Spongiform Encephalopathies (prion diseases). While cells typically recognize and process misfolded proteins, prion proteins evade protective measures by forming stable, self-replicating aggregates. However, co...

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Detalhes bibliográficos
Main Authors: DiSalvo, Susanne, Derdowski, Aaron, Pezza, John A., Serio, Tricia R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082495/
https://ncbi.nlm.nih.gov/pubmed/21423195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2031
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