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Selective Enhancement of Nucleases by Polyvalent DNA-Functionalized Gold Nanoparticles

We demonstrate that polyvalent DNA-functionalized gold nanoparticles (DNA-Au NPs) selectively enhance Ribonuclease H (RNase H) activity, while inhibiting most biologically relevant nucleases. This combination of properties is particularly interesting in the context of gene regulation, since high RNa...

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Detalhes bibliográficos
Main Authors: Prigodich, Andrew E., Alhasan, Ali H., Mirkin, Chad A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081637/
https://ncbi.nlm.nih.gov/pubmed/21268581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja110833r
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