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Gene Regulation with Polyvalent siRNA-Nanoparticle Conjugates

We report the synthesis and characterization of polyvalent RNA-gold nanoparticle conjugates (RNA-Au NPs), nanoparticles that are densely functionalized with synthetic RNA oligonucleotides and designed to function in the RNAi pathway. The particles were rationally designed and synthesized to be free...

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Detalhes bibliográficos
Main Authors: Giljohann, David A., Seferos, Dwight S., Prigodich, Andrew E., Patel, Pinal C., Mirkin, Chad A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843496/
https://ncbi.nlm.nih.gov/pubmed/19170493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja808719p
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