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Topical delivery of siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation

Topical application of nucleic acids offers many potential therapeutic advantages for suppressing genes in the skin, and potentially for systemic gene delivery. However, the epidermal barrier typically precludes entry of gene-suppressing therapy unless the barrier is disrupted. We now show that sphe...

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Bibliografische gegevens
Hoofdauteurs: Zheng, Dan, Giljohann, David A., Chen, David L., Massich, Matthew D., Wang, Xiao-Qi, Iordanov, Hristo, Mirkin, Chad A., Paller, Amy S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409786/
https://ncbi.nlm.nih.gov/pubmed/22773805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118425109
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