A Yersinia Effector with Enhanced Inhibitory Activity on the NF-κB Pathway Activates the NLRP3/ASC/Caspase-1 Inflammasome in Macrophages

A type III secretion system (T3SS) in pathogenic Yersinia species functions to translocate Yop effectors, which modulate cytokine production and regulate cell death in macrophages. Distinct pathways of T3SS-dependent cell death and caspase-1 activation occur in Yersinia-infected macrophages. One pat...

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Bibliografiske detaljer
Main Authors: Zheng, Ying, Lilo, Sarit, Brodsky, Igor E., Zhang, Yue, Medzhitov, Ruslan, Marcu, Kenneth B., Bliska, James B.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080847/
https://ncbi.nlm.nih.gov/pubmed/21533069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002026
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