Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling

We recently described the induction of noncanonical IL-1β processing via caspase-8 recruited to ripoptosome signaling platforms in myeloid leukocytes. Here, we demonstrate that activated NLRP3·ASC inflammasomes recruit caspase-8 to drive IL-1β processing in murine bone marrow-derived dendritic cells...

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Vydáno v:J Biol Chem
Hlavní autoři: Antonopoulos, Christina, Russo, Hana M., El Sanadi, Caroline, Martin, Bradley N., Li, Xiaoxia, Kaiser, William J., Mocarski, Edward S., Dubyak, George R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536427/
https://ncbi.nlm.nih.gov/pubmed/26100631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.652321
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