Rapid Temporal Control of Foxp3 Protein Degradation by Sirtuin-1

Maintenance of Foxp3 protein expression in regulatory T cells (Treg) is crucial for a balanced immune response. We have previously demonstrated that Foxp3 protein stability can be regulated through acetylation, however the specific mechanisms underlying this observation remain unclear. Here we demon...

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Main Authors: van Loosdregt, Jorg, Brunen, Diede, Fleskens, Veerle, Pals, Cornelieke E. G. M., Lam, Eric W. F., Coffer, Paul J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080399/
https://ncbi.nlm.nih.gov/pubmed/21533107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019047
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