Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells

Summary: The Foxp3 transcription factor is a crucial determinant of both regulatory T (TREG) cell development and their functional maintenance. Appropriate modulation of tolerogenic immune responses therefore requires the tight regulation of Foxp3 transcriptional output, and this involves both trans...

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Detalhes bibliográficos
Main Authors: Veerle Fleskens, Carlos M. Minutti, Xingmei Wu, Ping Wei, Cornelieke E.G.M. Pals, James McCrae, Saskia Hemmers, Vincent Groenewold, Harm-Jan Vos, Alexander Rudensky, Fan Pan, Huabin Li, Dietmar M. Zaiss, Paul J. Coffer
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019-03-01
Colecção:Cell Reports
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211124719302736
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