Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity

Stable Foxp3 expression is required for the development of functional regulatory T (Treg) cells. Here, we demonstrate that the expression of the transcription factor Foxp3 can be regulated through the polyubiquitination of multiple lysine residues, resulting in proteasome-mediated degradation. Expre...

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Detalhes bibliográficos
Main Authors: van Loosdregt, Jorg, Fleskens, Veerle, Fu, Juan, Brenkman, Arjan B., Bekker, Cornelis P.J., Pals, Cornelieke E.G.M., Meerding, Jenny, Berkers, Celia R., Barbi, Joseph, Gröne, Andrea, Sijts, Alice J.A.M., Maurice, Madelon M., Kalkhoven, Eric, Prakken, Berent J., Ovaa, Huib, Pan, Fan, Zaiss, Dietmar M.W., Coffer, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133784/
https://ncbi.nlm.nih.gov/pubmed/23973222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.05.018
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