Tara up-regulates E-cadherin transcription by binding to the Trio RhoGEF and inhibiting Rac signaling

The spatiotemporal regulation of E-cadherin expression is important during body plan development and carcinogenesis. We found that Tara (Trio-associated repeat on actin) is enriched in cadherin-based adherens junctions (AJs), and its knockdown in MDCK cells (Tara-KD cells) significantly decreases th...

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Bibliografiske detaljer
Main Authors: Yano, Tomoki, Yamazaki, Yuji, Adachi, Makoto, Okawa, Katsuya, Fort, Philippe, Uji, Masami, Tsukita, Shoichiro, Tsukita, Sachiko
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2011
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080255/
https://ncbi.nlm.nih.gov/pubmed/21482718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201009100
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