Flow-induced endothelial cell alignment requires the RhoGEF Trio as a scaffold protein to polarize active Rac1 distribution

Endothelial cells line the lumen of the vessel wall and are exposed to flow. In linear parts of the vessel, the endothelial cells experience laminar flow, resulting in endothelial cell alignment in the direction of flow, thereby protecting the vessel wall from inflammation and permeability. In order...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Biol Cell
Prif Awduron: Kroon, Jeffrey, Heemskerk, Niels, Kalsbeek, Martin J. T., de Waard, Vivian, van Rijssel, Jos, van Buul, Jaap D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Cell Biology 2017
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491183/
https://ncbi.nlm.nih.gov/pubmed/28515142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-06-0389
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