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Some Binding-Related Drug Properties are Dependent on Thermodynamic Signature
The binding affinity is determined by the Gibbs energy of binding (ΔG) which is the sum of enthalpic (ΔH) and entropic (-TΔS) contributions. Because the enthalpy and entropy contribute in an additive way to the binding energy, the same binding affinity can be achieved by many different combinations...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3079564/ https://ncbi.nlm.nih.gov/pubmed/21288305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2010.01075.x |
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