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Dynamics of Uracil and 5-Fluorouracil in DNA
The pro-drug 5-fluorouracil (5-FU), after activation into 5-F-dUMP, is an extensively used anticancer agent that inhibits thymidylate synthase and leads to increases in dUTP and 5-F-dUTP levels in cells. One mechanism for 5-FU action involves DNA polymerase mediated incorporation of dUTP and 5-F-dUT...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3079343/ https://ncbi.nlm.nih.gov/pubmed/21190322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101536k |
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