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Linking uracil base excision repair and 5-fluorouracil toxicity in yeast
5-fluorouracil (5-FU) is a widely used anticancer drug that disrupts pyrimidine nucleotide pool balances and leads to uracil incorporation in DNA, which is then recognized and removed by the uracil base excision repair (BER) pathway. Using complementary biochemical and genetic approaches we have exa...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2006
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1326247/ https://ncbi.nlm.nih.gov/pubmed/16407331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkj430 |
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