Llwytho...
Dynamics of Uracil and 5-Fluorouracil in DNA
The pro-drug 5-fluorouracil (5-FU), after activation into 5-F-dUMP, is an extensively used anticancer agent that inhibits thymidylate synthase and leads to increases in dUTP and 5-F-dUTP levels in cells. One mechanism for 5-FU action involves DNA polymerase mediated incorporation of dUTP and 5-F-dUT...
Wedi'i Gadw mewn:
| Prif Awduron: | , |
|---|---|
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2011
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3079343/ https://ncbi.nlm.nih.gov/pubmed/21190322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101536k |
| Tagiau: |
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