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Dynamics of Uracil and 5-Fluorouracil in DNA

The pro-drug 5-fluorouracil (5-FU), after activation into 5-F-dUMP, is an extensively used anticancer agent that inhibits thymidylate synthase and leads to increases in dUTP and 5-F-dUTP levels in cells. One mechanism for 5-FU action involves DNA polymerase mediated incorporation of dUTP and 5-F-dUT...

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Bibliografische gegevens
Hoofdauteurs: Parker, Jared B., Stivers, James T.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3079343/
https://ncbi.nlm.nih.gov/pubmed/21190322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101536k
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