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Enzymatic Capture of a Transient Extrahelical Thymine in the Search for Uracil in DNA
The enzyme uracil DNA glycosylase (UNG) excises unwanted uracil bases in the genome using an extrahelical base recognition mechanism. Efficient removal of uracil is essential for prevention of C➔T transition mutations arising from cytosine deamination, cytotoxic U:A pairs arising from incorporation...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2754044/ https://ncbi.nlm.nih.gov/pubmed/17704764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06131 |
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