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Enzymatic Capture of a Transient Extrahelical Thymine in the Search for Uracil in DNA

The enzyme uracil DNA glycosylase (UNG) excises unwanted uracil bases in the genome using an extrahelical base recognition mechanism. Efficient removal of uracil is essential for prevention of C➔T transition mutations arising from cytosine deamination, cytotoxic U:A pairs arising from incorporation...

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Detalhes bibliográficos
Main Authors: Parker, Jared B., Bianchet, Mario A., Krosky, Daniel J., Friedman, Joshua I., Amzel, L. Mario, Stivers, James T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754044/
https://ncbi.nlm.nih.gov/pubmed/17704764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06131
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