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Cosolute Paramagnetic Relaxation Enhancements Detect Transient Conformations of Human Uracil DNA Glycosylase (hUNG)
The human DNA repair enzyme uracil DNA glycosylase (hUNG) locates and excises rare uracil bases that arise in DNA from cytosine deamination or through dUTP incorporation by DNA polymerases. Previous NMR studies of hUNG have revealed millisecond time scale dynamic transitions in the enzyme-nonspecifi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3232301/ https://ncbi.nlm.nih.gov/pubmed/22077282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201572g |
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