Uracil-DNA Glycosylase UNG Promotes Tet-mediated DNA Demethylation

In mammals, active DNA demethylation involves oxidation of 5-methylcytosine (5mC) into 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) by Tet dioxygenases and excision of these two oxidized bases by thymine DNA glycosylase (TDG). Although TDG is essential for active demethylation in embryonic s...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Xue, Jian-Huang, Xu, Gui-Fang, Gu, Tian-Peng, Chen, Guo-Dong, Han, Bin-Bin, Xu, Zhi-Mei, Bjørås, Magnar, Krokan, Hans E., Xu, Guo-Liang, Du, Ya-Rui
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
DNA and Chromosomes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705393/
https://ncbi.nlm.nih.gov/pubmed/26620559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.693861
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