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Linking uracil base excision repair and 5-fluorouracil toxicity in yeast

5-fluorouracil (5-FU) is a widely used anticancer drug that disrupts pyrimidine nucleotide pool balances and leads to uracil incorporation in DNA, which is then recognized and removed by the uracil base excision repair (BER) pathway. Using complementary biochemical and genetic approaches we have exa...

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Bibliografski detalji
Glavni autori: Seiple, Lauren, Jaruga, Pawel, Dizdaroglu, Miral, Stivers, James T.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2006
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1326247/
https://ncbi.nlm.nih.gov/pubmed/16407331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkj430
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