ERK-MAPK Drives Lamellipodia Protrusion by Activating the WAVE2 Regulatory Complex

Cell movement begins with a leading edge protrusion, which is stabilized by nascent adhesions and retracted by mature adhesions. The ERK-MAPK (extracellular signal regulated kinasemitogen-activated protein kinase) localizes to protrusions and adhesions, but how it regulates motility is not understoo...

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Bibliographic Details
Main Authors: Mendoza, Michelle C., Emrah, E., Zhang, Wenjuan, Ballif, Bryan A., Elliott, Hunter L., Danuser, Gaudenz, Blenis, John
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078620/
https://ncbi.nlm.nih.gov/pubmed/21419341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.02.031
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