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The WAVE Regulatory Complex Is Required to Balance Protrusion and Adhesion in Migration

Cells migrating over 2D substrates are required to polymerise actin at the leading edge to form lamellipodia protrusions and nascent adhesions to anchor the protrusion to the substrate. The major actin nucleator in lamellipodia formation is the Arp2/3 complex, which is activated by the WAVE regulato...

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Detalhes bibliográficos
Publicado no:Cells
Main Authors: Whitelaw, Jamie A., Swaminathan, Karthic, Kage, Frieda, Machesky, Laura M.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7407199/
https://ncbi.nlm.nih.gov/pubmed/32646006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9071635
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