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The WAVE Regulatory Complex Is Required to Balance Protrusion and Adhesion in Migration

Cells migrating over 2D substrates are required to polymerise actin at the leading edge to form lamellipodia protrusions and nascent adhesions to anchor the protrusion to the substrate. The major actin nucleator in lamellipodia formation is the Arp2/3 complex, which is activated by the WAVE regulato...

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Bibliografski detalji
Izdano u:Cells
Glavni autori: Whitelaw, Jamie A., Swaminathan, Karthic, Kage, Frieda, Machesky, Laura M.
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7407199/
https://ncbi.nlm.nih.gov/pubmed/32646006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9071635
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