Coordination of Rho GTPase activities during cell protrusion

The GTPases Rac1, RhoA and Cdc42 act in concert to control cytoskeleton dynamics1-3. Recent biosensor studies have shown that all three GTPases are activated at the front of migrating cells4-7 and biochemical evidence suggests that they may regulate one another: Cdc42 can activate Rac18, and Rac1 an...

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Bibliografiske detaljer
Main Authors: Machacek, Matthias, Hodgson, Louis, Welch, Christopher, Elliott, Hunter, Pertz, Olivier, Nalbant, Perihan, Abell, Amy, Johnson, Gary L., Hahn, Klaus M., Danuser, Gaudenz
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885353/
https://ncbi.nlm.nih.gov/pubmed/19693013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08242
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