Voltage-Dependent Gating Underlies Loss of ENaC Function in Pseudohypoaldosteronism Type 1

Here we explore the mechanism and associated structure-function implications of loss of function for epithelial Na(+) channel (ENaC) containing a pseudohypoaldosteronism type 1 (PHA-1)-causing missense point mutation. As expected, human ENaC that contained subunits harboring PHA-1-causing substituti...

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Bibliografiske detaljer
Main Authors: Kucher, Volodymyr, Boiko, Nina, Pochynyuk, Oleh, Stockand, James D.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2011
Fag:
Channels and Transporters
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077708/
https://ncbi.nlm.nih.gov/pubmed/21504729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.02.046
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