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Voltage-Dependent Gating Underlies Loss of ENaC Function in Pseudohypoaldosteronism Type 1
Here we explore the mechanism and associated structure-function implications of loss of function for epithelial Na(+) channel (ENaC) containing a pseudohypoaldosteronism type 1 (PHA-1)-causing missense point mutation. As expected, human ENaC that contained subunits harboring PHA-1-causing substituti...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3077708/ https://ncbi.nlm.nih.gov/pubmed/21504729 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.02.046 |
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