Llwytho...

Voltage-Dependent Gating Underlies Loss of ENaC Function in Pseudohypoaldosteronism Type 1

Here we explore the mechanism and associated structure-function implications of loss of function for epithelial Na(+) channel (ENaC) containing a pseudohypoaldosteronism type 1 (PHA-1)-causing missense point mutation. As expected, human ENaC that contained subunits harboring PHA-1-causing substituti...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kucher, Volodymyr, Boiko, Nina, Pochynyuk, Oleh, Stockand, James D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Biophysical Society 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077708/
https://ncbi.nlm.nih.gov/pubmed/21504729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.02.046
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!