Distinct Complexes of DNA Polymerase I (Klenow Fragment) for Base and Sugar Discrimination during Nucleotide Substrate Selection

During each catalytic cycle, DNA polymerases select deoxyribonucleoside triphosphate (dNTP) substrates complementary to a templating base with high fidelity from a pool that includes noncomplementary dNTPs and both complementary and noncomplementary ribonucleoside triphosphates (rNTPs). The Klenow f...

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Bibliographische Detailangaben
Hauptverfasser: Garalde, Daniel R., Simon, Christopher A., Dahl, Joseph M., Wang, Hongyun, Akeson, Mark, Lieberman, Kate R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077647/
https://ncbi.nlm.nih.gov/pubmed/21362617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.218750
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