A Specific Two-pore Domain Potassium Channel Blocker Defines the Structure of the TASK-1 Open Pore

Two-pore domain potassium (K(2P)) channels play a key role in setting the membrane potential of excitable cells. Despite their role as putative targets for drugs and general anesthetics, little is known about the structure and the drug binding site of K(2P) channels. We describe A1899 as a potent an...

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Detaylı Bibliyografya
Asıl Yazarlar: Streit, Anne K., Netter, Michael F., Kempf, Franca, Walecki, Magdalena, Rinné, Susanne, Bollepalli, Murali K., Preisig-Müller, Regina, Renigunta, Vijay, Daut, Jürgen, Baukrowitz, Thomas, Sansom, Mark S. P., Stansfeld, Phillip J., Decher, Niels
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2011
Konular:
Protein Structure and Folding
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077598/
https://ncbi.nlm.nih.gov/pubmed/21362619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.227884
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