RNA editing modulates the binding of drugs and highly unsaturated fatty acids to the open pore of Kv potassium channels

The time course of inactivation of voltage-activated potassium (Kv) channels is an important determinant of the firing rate of neurons. In many Kv channels highly unsaturated lipids as arachidonic acid, docosahexaenoic acid and anandamide can induce fast inactivation. We found that these lipids inte...

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Detalhes bibliográficos
Main Authors: Decher, Niels, Streit, Anne K, Rapedius, Markus, Netter, Michael F, Marzian, Stefanie, Ehling, Petra, Schlichthörl, Günter, Craan, Tobias, Renigunta, Vijay, Köhler, Annemarie, Dodel, Richard C, Navarro-Polanco, Ricardo A, Preisig-Müller, Regina, Klebe, Gerhard, Budde, Thomas, Baukrowitz, Thomas, Daut, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905254/
https://ncbi.nlm.nih.gov/pubmed/20461057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.88
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