RNA editing modulates the binding of drugs and highly unsaturated fatty acids to the open pore of Kv potassium channels

The time course of inactivation of voltage-activated potassium (Kv) channels is an important determinant of the firing rate of neurons. In many Kv channels highly unsaturated lipids as arachidonic acid, docosahexaenoic acid and anandamide can induce fast inactivation. We found that these lipids inte...

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Bibliografiske detaljer
Main Authors: Decher, Niels, Streit, Anne K, Rapedius, Markus, Netter, Michael F, Marzian, Stefanie, Ehling, Petra, Schlichthörl, Günter, Craan, Tobias, Renigunta, Vijay, Köhler, Annemarie, Dodel, Richard C, Navarro-Polanco, Ricardo A, Preisig-Müller, Regina, Klebe, Gerhard, Budde, Thomas, Baukrowitz, Thomas, Daut, Jürgen
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905254/
https://ncbi.nlm.nih.gov/pubmed/20461057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.88
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