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Side pockets provide the basis for a new mechanism of Kv channel–specific inhibition
Most known small-molecule inhibitors of voltage-gated ion channels have poor subtype specificity because they interact with a highly conserved binding site in the central cavity. Using alanine-scanning mutagenesis, electrophysiological recordings and molecular modeling, we have identified a new drug...
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| Publicado no: | Nat Chem Biol |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4539245/ https://ncbi.nlm.nih.gov/pubmed/23728494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1271 |
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