RNA Editing in the Central Cavity as a Mechanism to Regulate Surface Expression of the Voltage-gated Potassium Channel Kv1.1

Voltage-gated potassium (Kv) 1.1 channels undergo a specific enzymatic RNA deamination, generating a channel with a single amino acid exchange located in the inner pore cavity (Kv1.1(I400V)). We studied I400V-edited Kv1.1 channels in more detail and found that Kv1.1(I400V) gave rise to much smaller...

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Autors principals: Streit, Anne K., Matschke, Lina A., Dolga, Amalia M., Rinné, Susanne, Decher, Niels
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
Molecular Biophysics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175319/
https://ncbi.nlm.nih.gov/pubmed/25100718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.545731
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