A Specific Two-pore Domain Potassium Channel Blocker Defines the Structure of the TASK-1 Open Pore

Two-pore domain potassium (K(2P)) channels play a key role in setting the membrane potential of excitable cells. Despite their role as putative targets for drugs and general anesthetics, little is known about the structure and the drug binding site of K(2P) channels. We describe A1899 as a potent an...

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Dades bibliogràfiques
Autors principals: Streit, Anne K., Netter, Michael F., Kempf, Franca, Walecki, Magdalena, Rinné, Susanne, Bollepalli, Murali K., Preisig-Müller, Regina, Renigunta, Vijay, Daut, Jürgen, Baukrowitz, Thomas, Sansom, Mark S. P., Stansfeld, Phillip J., Decher, Niels
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077598/
https://ncbi.nlm.nih.gov/pubmed/21362619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.227884
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