Carregant...

State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1

We previously reported that TREK-1 gating by internal pH and pressure occurs close to or within the selectivity filter. These conclusions were based upon kinetic measurements of high-affinity block by quaternary ammonium (QA) ions that appeared to exhibit state-independent accessibility to their bin...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Rapedius, Markus, Schmidt, Matthias R., Sharma, Chetan, Stansfeld, Phillip J., Sansom, Mark S.P., Baukrowitz, Thomas, Tucker, Stephen J.
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536734/
https://ncbi.nlm.nih.gov/pubmed/22991046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/chan.22153
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!