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Pharmacologically induced alcohol craving in treatment seeking alcoholics correlates with alcoholism severity, but is insensitive to acamprosate

Modulation of alcohol craving induced by challenge stimuli may predict the efficacy of new pharmacotherapies for alcoholism. We evaluated two pharmacological challenges, the α(2)-adrenergic antagonist yohimbine, which reinstates alcohol seeking in rats, and the serotonergic compound meta-chloropheny...

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Detalhes bibliográficos
Main Authors: Umhau, John C, Schwandt, Melanie L, Usala, Julie, Geyer, Christopher, Singley, Erick, George, David T, Heilig, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077446/
https://ncbi.nlm.nih.gov/pubmed/21289601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2010.253
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