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Lidocaine partially depolarizes the S4 segment in domain IV of the sodium channel
Previous studies have shown that lidocaine and other local anesthetic drugs (LAs) cause use-dependent block of sodium current (I(Na)), i.e., block that increases with membrane depolarization by allosteric coupling between drug binding in the inner pore and the S4s in domains III and IV. MTSET protec...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3076088/ https://ncbi.nlm.nih.gov/pubmed/20981437 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-010-0894-1 |
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