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Lidocaine partially depolarizes the S4 segment in domain IV of the sodium channel

Previous studies have shown that lidocaine and other local anesthetic drugs (LAs) cause use-dependent block of sodium current (I(Na)), i.e., block that increases with membrane depolarization by allosteric coupling between drug binding in the inner pore and the S4s in domains III and IV. MTSET protec...

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Détails bibliographiques
Auteurs principaux: Sheets, Michael F., Chen, Tiehua, Hanck, Dorothy A.
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076088/
https://ncbi.nlm.nih.gov/pubmed/20981437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-010-0894-1
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