Loading...
Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels
The anti-arrhythmic drug lidocaine has been shown to have a lower affinity for block of voltage-gated sodium channels at hyperpolarized potentials compared to depolarized potentials. Concomitantly, lidocaine reduces maximum gating charge (Q(max)) by 40% resulting from the complete stabilization of t...
Na minha lista:
| Main Authors: | , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Blackwell Science Inc
2007
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2075305/ https://ncbi.nlm.nih.gov/pubmed/17510181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.134262 |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|