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Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels
The anti-arrhythmic drug lidocaine has been shown to have a lower affinity for block of voltage-gated sodium channels at hyperpolarized potentials compared to depolarized potentials. Concomitantly, lidocaine reduces maximum gating charge (Q(max)) by 40% resulting from the complete stabilization of t...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2075305/ https://ncbi.nlm.nih.gov/pubmed/17510181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.134262 |
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