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The outermost lysine in the S4 of domain III contributes little to the gating charge in sodium channels.

We investigated the contribution the four outermost basic residues (K1, R2, R3, R4) in segment 4 of domain III in the human cardiac Na channel (hH1a, Na(V)1.5) to the total gating charge (Q(max)). Each of the four basic residues were mutated individually to a cysteine. In addition, R2 was also mutat...

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Bibliografske podrobnosti
Main Authors: Sheets, Michael F, Hanck, Dorothy A
Format: Artigo
Jezik:Inglês
Izdano: 2002
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302092/
https://ncbi.nlm.nih.gov/pubmed/12023227
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